Dynamic changes in CREB phosphorylation and neuroadaptive gene expression in area V1 of adult monkeys after monocular enucleation

作者：Lalonde Jasmin^*; Chaudhuri Avi

来源：Molecular and Cellular Neuroscience, 2007, 35(1): 24-37.

DOI：10.1016/j.mcn.2007.01.015

• CREB
• Bcl-2.
• Bcl-w
• monocular enucleation
• neuroplasticity
• neuroadaptation
• primary visual cortex
• primate

Our understanding of the molecular events that emerge after change in sensory input remains elusive, especially with regard to mature area V1. Here, we characterized P-CREB expression in area V1 of monkeys at multiple time-points after monocular enucleation (ME) to assess the possible contribution of CREB in visually deprived neocortex. Immunoblot assays and immunostainings showed that P-CREB is dynamically regulated in adult area VI, reaching a peak level between 5 and 30 days after ME, and becoming reduced at the 90-day post-ME time-point. This striking temporal increase in P-CREB level was paralleled by a concomitant increase of two CREB-regulated prosurvival effectors, namely Bcl-2 and Bcl-w. We present our results in the context of recent advances about adult visual neocortex and propose that ME induces a multifaceted CREB-mediated response that favors intrinsic stability of neurons and facilitates mature cortical networks to reorganize over a prolonged period.

• 出版日期2007-5