科研之友
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摘要
ObjectiveSerum sex steroid concentrations may alter body composition and glucose homoeostasis in men in a dose-response manner. We evaluated these end-points in healthy men rendered medically castrate through use of a gonadotrophin-releasing hormone antagonist (acyline) with incremental doses of exogenous testosterone (T) gel. DesignSubjects (n=6-9 per group) were randomly assigned to injections of acyline every 2weeks plus transdermal T gel (1.25g, 2.5g, 5.0g, 10g or 15g) daily or double placebo (injections and gel) for 12weeks. PatientsHealthy men, ages 25-55years, with normal serum total T concentrations. MeasurementsSerum T, dihydrotestosterone (DHT) and oestradiol (E2) were measured at baseline and every 2weeks. Body composition was analysed by dual-energy X-ray absorptiometry at baseline and week 12. Fasting serum adiponectin, leptin, glucose and insulin concentrations were measured at baseline and week 10. ResultsForty-eight men completed the study. A significant treatment effect was observed for change in lean mass (ANOVAP=.01) but not fat mass (P=.14). Lean mass increased in the 15g T group relative to all lower dose groups, except the 10g T group. When all subjects were analysed together, changes in lean mass correlated directly and changes in fat mass correlated inversely with serum T, E2 and DHT. No changes were noted in serum glucose, insulin or adipokine levels. ConclusionsIn healthy men, higher serum concentrations of T, DHT and E2 were associated with greater increases in lean mass and decreases in fat mass but not with changes in serum glucose, insulin or adipokines.
- 出版日期2017-7
