Antioxidant and cytotoxic activities investigation of tomato seed extracts

作者：Tommonaro Giuseppina^*; Caporale Angelamaria; De Martino Laura; Popolo Ada; De Prisco Rocco; Nicolaus Barbara; Abbamondi Gennaro Roberto; Saturnino Carmela

来源：Natural Product Research, 2014, 28(10): 764-768.

DOI：10.1080/14786419.2013.879474

• Tomato
• antioxidant activity
• cytotoxicity
• seed extracts

Biological activities of different varieties of tomato seed extracts were evaluated to verify the potential antioxidant and/or antiproliferative activity of the bioactive metabolites present in them. Findings demonstrated that among all the varieties investigated (San Marzano Rosso, San Marzano Giallo, Corbarino, Black Tomato and San Marzano/Black Tomato hybrid) San Marzano Rosso seed extract exhibited the highest free radical-scavenging activity with 68% of 2,2-Diphenyl-1-picrylhydrazyl radical inhibition, and the best cytotoxic activity evaluated by using the brine shrimp test (LD50: 23,198ppm) and 3-(4,5-dimethylthiazol-2-yl)-2,5-phenyl-2H-tetrazolium bromide assay on A375 cell line (IC50: 137.7g/mL).

• 出版日期2014-5-19