A new sensitive flow-injection chemiluminescence method for the determination of H-2-receptor antagonists

作者：Tang Yu Hai^*; Wang Nan Nan; Xiong Xun Yu; Xiong Feng Mei; Sun Si Juan

来源：Luminescence, 2007, 22(4): 343-348.

DOI：10.1002/bio.969

• flow injection
• chemiluminescence
• cimetidine
• ranitidine
• famotidine

Based on the chemi luminescence (CL) intensity generated from the potassium ferricyanide [K3Fe(CN)(6)]-rhodamine 6G system in sodium hydroxide (NaOH) medium, a new sensitive flow-injection chemiluminescence (FI-CL) method has been developed, validated and applied for the determination of three kinds of H-2-receptor antagonists: cimetidine (CIMT), ranitidine (RANT) hydrochloride and famotidine (FAMT). Under the optimum conditions, the linear range for the determination was 1.0 x 10(-9)-7.0 x 10(-5) g/ml for CIMT, 1.0 x 10(-9)-5.0 x 10(-5) g/mL for RANT hydrochloride and 5.0 x 10(-9)-7.0 x 10(-5) g/mL for FAMT. During I I repeated measurements of 1.0 x 10(-6) g/mL sample solutions, the relative standard deviations (RSDs) were all <5%. The detection limit was 8.56 x 10(-10) g/mL for CIMT, 8.69 x 10(-10) g/mL for RANT hydrochloride and 2.35 x 10(-9) g/mL for FAMT (S:N = 3). This method has been successfully implemented for the analysis of H,-receptor antagonists in pharmaceuticals.

• 出版日期2007-8
• 单位西安交通大学