A cyanobiphenyl based fluorescent probe for rapid and specific detection of hypochlorite and its bio-imaging applications

作者：Tang, Xu; Zhu, Zhi; Wang, Yun^*; Han, Juan; Ni, Liang^*; Zhang, Huiqin; Li, Jing; Mao Yanli

来源：Sensors and Actuators B: Chemical , 2018, 262: 57-63.

DOI：10.1016/j.snb.2018.01.204

• Hypochlorite
• Fluorescent probe
• Cyanobiphenyl
• Cell imaging

A fluorescence probe (HBM) based on conjugation of 3'-formy1-4'-hydroxy-4-biphenylcarbonitrile to 2,4-dinitrophenylhydrazune for the detection of hypochlorite has been developed. The probe exhibited a highly sensitive and selective response toward hypochlorite (C10(-)) with a low detection limit of 49 nM. The sensing mechanism was considered that the hypochlorite triggered oxidative hydrolysis of probe HBM and the cyanobiphenyl fluorophore was released, which also have been evidenced by the MS analysis. Most notably, the response time of the probe HBM to the OC1(-) is only a few seconds. The probe was also successfully applied to fluorescence imaging of OC1(-) in the living cells.

• 出版日期2018-6-1
• 单位河南城建学院; 江苏大学