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摘要
Synthesis of novel 2-3-methyl-5-[(E)-2-aryl-1-ethenyl]-4-isoxazolyl-4,10a-diaryl-1,10a-dihydro-2H-benzo [d]pyrazino[2,1-b][1,3]oxazoles 5 were simply achieved by the reaction of 2-[3-methyl-5-[(E)-2-aryl-1-ethenyl]-4-isoxazolyl(2-oxo-2-arylethyl) amino]-1-aryl-1-ethanones 3 with o-aminophenol 4 in the presence of CAN catalyst. The intermediates, 2-[3-methyl-5-[(E)-2-aryl-1-ethenyl]-4-isoxazolyl(2-oxo-2-arylethyl) amino]-1-aryl-1-ethanones 3, were prepared by the reaction of 4-amino-3-methyl-5-styrylisoxazole 1, with phenacylbromides 2 in ethanol in the presence of K2CO3. The structures of the newly synthesized compounds 3a-l and 5a-l have been confirmed by analytical and spectral data.
- 出版日期2015-7
