Application of dual-energy spectral CT imaging in differential diagnosis of bladder cancer and benign prostate hyperplasia

作者：Chen, Anliang; Liu, Ailian^*; Liu, Jinghong; Tian, Shifeng; Wang, Heqing; Liu, Yijun

来源：Medicine, 2016, 95(52): e5705.

DOI：10.1097/MD.0000000000005705

• Benign prostate hyperplasia
• bladder cancer
• CT

The aim of this study was to explore the clinical value of dual-energy spectral CT imaging in the differential diagnosis between bladder cancer and benign prostate hyperplasia (BPH).
We retrospectively analyzed images of 118 patients who received pelvic dual-energy spectral CT imaging. These patients were later confirmed to have bladder cancer in 61 patients and BPH in 57 patients. CT values of the 2 lesion types from 40 to 140keV were measured from the monochromatic spectral CT image to generate spectral HU curves. The slope of the spectral curve and the lesion effective atomic number were calculated. The measured parameters were analyzed with independent-sample Mann-Whitney U test.
There was a statistically significant difference in CT value between the 2 groups from 40 to 90keV, with the biggest difference at 40 keV (median and interquartile range: 83.3HU and 22.9HU vs 60.6HU and 16.7HU, Z=5.932, P<0.001). The slope of the spectral HU curve for bladder cancer was markedly higher than that of BPH (median and interquartile range: 0.48 and 0.23 vs 0.26 and 0.22, Z=5.162, P<0.001); the difference in effective atomic number (median and interquartile range: 7.99 and 0.21 vs 7.80 and 0.20, Z=5.233, P<0.001) was also statistically significant.
Dual-energy spectral CT imaging provides high sensitivity and specificity for differentiating bladder cancer from benign prostate hyperplasia.

• 出版日期2016-12
• 单位大连医科大学