The Rome Transplant Network model compared to the Italian Bone Marrow Donor Registry activity for unrelated donor search process and transplant efficiency for hematologic malignancy

作者：Picardi Alessandra^*; Arcese William; Pollichieni Simona; Di Piazza Fabio; Mangione Ilaria; Gallina Anna Maria; Cerretti Raffaella; Cudillo Laura; De Angelis Gottardo; Mengarelli Andrea; Dentamaro Teresa; Tirindelli Maria Cristina; Chierichini Anna; Ferrari Antonella; Marciano Renato; Andreani Marco; Bonifazi Francesca; Sacchi Nicoletta

来源：Transfusion, 2017, 57(7): 1734-1743.

DOI：10.1111/trf.14131

BACKGROUND: From 2011 to 2014, a total of 71% of the 3834 patients with hematologic malignancies successfully identified a matched unrelated donor (MUD) through the Italian Bone Marrow Donor Registry (IBMDR), corresponding to a transplant efficiency of 62%.
STUDY DESIGN AND METHODS: From 2006, the Rome Transplant Network (RTN) followed a hierarchical selection strategy for the alternative donor search: first MUD, second cord blood, and third haploidentical donor. Using a low-resolution HLA, a preliminary query (PQ) was performed in all cases with assignment of good or poor score if more or less than 10 MUDs were identified in Bone Marrow Donors Worldwide. Herein we assessed the utility of PQ and of high-resolution (HR) HLA from the start of the search. Moreover, we compared the donor identification and the transplant efficiency between IBMDR and RTN.
RESULTS: At RTN 79% of 417 patients met a good PQ with a 50% MUD identification versus 12.5% with poor PQ. Our policy led to 78 and 74% of alternative donor identification and transplant efficiency, respectively, higher than IBMDR data equal to 71% (p50.007) and 62% (p< 0.0001). The timing for donor identification was significantly reduced using HR HLA at the start of the search from 88 to 66 days at IBMDR (p< 0.001) and from 61 to 41 days at RTN (p< 0.001).
CONCLUSIONS: Both PQ and HR HLA at the start of the process represents a useful tool to address the search towards the best and timely donor choice. Moreover, establishing a specific donor policy significantly improves the transplant efficiency.

• 出版日期2017-7