Murine xenograft model demonstrates significant radio-sensitising effect of liposomal doxorubicin in a combination therapy for Feline Injection Site Sarcoma

作者：Petznek H^*; Kleiter M; Tichy A; Fuchs Baumgartinger A; Hohenadl C

来源：Research in Veterinary Science, 2014, 97(2): 386-390.

DOI：10.1016/j.rvsc.2014.07.008

• FISS
• Doxorubicin
• Radiation
• Primary feline sarcoma cell culture
• Xenograft tumour mouse model

Therapy of cats suffering from feline injection site sarcomas (FISS) is still a challenging problem, as the recurrence rate after surgery is up to 70%. Four FISS-derived primary tumour cell lines and corresponding xenograft tumour mouse models were established to evaluate the efficacy of a concomitant chemo-/ radiation therapy with doxorubicin. In vitro, strongly depending upon the timing of administration, pretreatment with 0.25 mu mol doxorubicin resulted in a significant enhancement of radiation-induced (3.5 Gy) tumour cell death. This result was confirmed in vivo, where only the combined chemo-/radiation therapy resulted in a significant reduction in tumour growth compared to the respective mono-therapies with either doxorubicin or radiation. These results support the use of the concomitant chemo-/radiation therapy for adjuvant treatment of FISS, particularly in advanced or recurrent disease where surgery alone is no longer feasible.

• 出版日期2014-10