New semi-quantitative I-123-MIBG estimation method compared with scoring system in follow-up of advanced neuroblastoma: utility of total MIBG retention ratio versus scoring method

作者：Sano Yuko^*; Okuyama Chio; Iehara Tomoko; Matsushima Shigenori; Yamada Kei; Hosoi Hajime; Nishimura Tsunehiko

来源：Annals of Nuclear Medicine, 2012, 26(6): 462-470.

DOI：10.1007/s12149-012-0596-1

• Advanced neuroblastoma
• I-123-MIBG scintigraphy
• Scoring system
• Urinary vanillylmandelic acid
• Urinary homovanillic acid

The purpose of this study is to evaluate a new semi-quantitative estimation method using I-123-MIBG retention ratio to assess response to chemotherapy for advanced neuroblastoma. %26lt;br%26gt;Thirteen children with advanced neuroblastoma (International Neuroblastoma Risk Group Staging System: stage M) were examined for a total of 51 studies with I-123-MIBG scintigraphy (before and during chemotherapy). We proposed a new semi-quantitative method using MIBG retention ratio (count obtained with delayed image/count obtained with early image with decay correction) to estimate MIBG accumulation. We analyzed total I-123-MIBG retention ratio (TMRR: total body count obtained with delayed image/total body count obtained with early image with decay correction) and compared with a scoring method in terms of correlation with tumor markers. %26lt;br%26gt;TMRR showed significantly higher correlations with urinary catecholamine metabolites before chemotherapy (VMA: r (2) = 0.45, P %26lt; 0.05, HVA: r (2) = 0.627, P %26lt; 0.01) than MIBG score (VMA: r (2) = 0.19, P = 0.082, HVA: r (2) = 0.25, P = 0.137). There were relatively good correlations between serial change of TMRR and those of urinary catecholamine metabolites (VMA: r (2) = 0.274, P %26lt; 0.001, HVA: r (2) = 0.448, P %26lt; 0.0001) compared with serial change of MIBG score and those of tumor markers (VMA: r (2) = 0.01, P = 0.537, HVA: 0.084, P = 0.697) during chemotherapy for advanced neuroblastoma. %26lt;br%26gt;TMRR could be a useful semi-quantitative method for estimating early response to chemotherapy of advanced neuroblastoma because of its high correlation with urine catecholamine metabolites.

• 出版日期2012-7