Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity

作者：Varga Gabor; Szekely Anna^*; Antal Peter; Sarkozy Peter; Nemoda Zsofia; Demetrovics Zsolt; Sasvari Szekely Maria

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2012, 159B(3): 281-288.

DOI：10.1002/ajmg.b.32025

• individual differences
• impulsivity trait
• dopamine D4 receptor
• serotonin receptor
• HTR1B

Twin studies suggest 45% heritability of trait impulsivity. Results from candidate gene studies to date are contradictory; impulsivity phenotypes were measured by different behavioral and questionnaire methods related either to the dopaminergic or to the serotonergic system. Here we report an association study of both dopaminergic (COMT rs4680, DRD4 48?bp VNTR, DRD2/ANKK1 rs1800497) and serotonergic (HTR1A rs6925, HTR1B rs13212041, SLC6A4 5-HTTLPR) gene polymorphisms and trait impulsivity assessed with the Barratt Impulsiveness Scale (BIS-11) in a sample of 687 Caucasian young adults. Results showed lower impulsivity in the presence of the DRD4 7-repeat (P?=?0.006) and the HTR1B rs13212041 alleles (P?=?0.003). These findings stayed significant after Bonferroni correction. A multivariate analysis using Bayesian networks confirmed independent effects of these two polymorphisms and provided a coherent characterization of the system of dependencies with respect to the impulsivity construct as well as its subscales. These results clearly suggest an additive effect of dopaminergic and serotonergic polymorphisms on trait impulsivity.

• 出版日期2012-4
• 单位河北医科大学