Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)

作者：Medina Rebeca P; de Moura Vagner M; da Silva Cleuza C; de Oliveira Cecilia M A; Kato Lucilia; Pomini Armando M; de Carvalho Joao E; Ruiz Ana Lucia T G; Bersani Amado Ciomar A; Santin Silvana M O^*

来源：Natural Product Research, 2018, 32(11): 1357-1360.

DOI：10.1080/14786419.2017.1344654

• Ixora brevifolia
• Rubiaceae
• antiproliferative activity
• anti-inflammatory activity

The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line.
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• 出版日期2018