Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population

作者：Sun, Shilong; Wang, Fan; Wei, Jun; Cao, Lian Yuan; Wu, Gui Ying; Lu, Lin; Kosten, Therese A.; Kosten, Thomas R.; Zhang, Xiang Yang^*

来源：Neuroscience Letters, 2008, 440(1): 35-37.

DOI：10.1016/j.neulet.2008.05.029

• schizophrenia
• interleukin-3 receptor
• polymorphism
• association
• cytokine

Schizophrenia has been observed to be associated with various abnormalities in cytokines and cytokine receptors. Three very recent reports showed the evidence that the IL3 gene, colony stimulating factor 2 receptor alpha (CSF2RA), beta (CSF2RB) and IL-3 receptor alpha (IL3RA), the IL-specific receptor sub-units for CSF2 and IL3, respectively, are associated with schizophrenia. To examine the association of the IBRA polymorphism (rs6603272) with schizophrenia in a Chinese population, 310 physically healthy patients with schizophrenia were compared with 330 age-, sex-matched normal controls. Statistically significant differences were observed in both allelic and genotypic frequencies of the rs6603272 polymorphism (Allele, chi(2) = 6.24, d.f. = 1, p =0.013, odds ratio (OR)= 1.35, 95% Cl 1.07-1.71; Genotype, chi(2) = 6.85, d.f. = 2, p = 0.033). Our results indicate a small but significant contribution of the IBRA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia.

• 出版日期2008-7-25
• 单位吉林大学; 北京回龙观医院; 北京大学