Association of Urinary Cesium with Breast Cancer Risk

作者：Qin, Ya-Chao^*; Tang, Lu-Ying; Su, Yi; Chen, Li-Juan; Su, Feng-Xi; Lin, Ying; Zhang, Ai-Hua; Ren, Ze-Fang

来源：Asian Pacific Journal of Cancer Prevention, 2014, 15(22): 9785-9790.

DOI：10.7314/APJCP.2014.15.22.9785

• Cesium
• breast cancer
• urine
• risk

Background: The aim of this study is to examine the association of urinary cesium with breast cancer risk. Materials and Methods: We collected survey data and urine specimens from 240 women with incident invasive breast cancer before their treatment and 246 age-matched female controls between October 2009 and July 2010. Urinary concentrations of cesium were determined by inductively coupled plasma mass spectrometry. Interviews were conducted by face-to-face to obtain information on potential breast cancer risk factors. Logistic regression analysis was used to estimate the associations. Results: Creatinine-adjusted levels [median (25th, 75th) ug/g] of cesium in cases and controls were 17.6 (13.1, 24.0) and 19.3 (15.3, 25.7), respectively. After adjustment for potential risk factors, women in the second and highest tertile of cesium showed a decreased risk of breast cancer in a dose-dependent manner as compared with those in the lowest tertile [ORs and 95% CIs: 0.75 (0.46-1.22) and 0.50 (0.30-0.82), respectively]. This decrease was more evident in women with ER positive or localized clinical stage in an exploratory stratification analysis. Conclusions: These findings suggest that cesium may have anticancer efficacy and urinary cesium has potential as a biomarker for breast cancer risk assessment.

• 出版日期2014
• 单位中山大学