Accuracy of Malaria Diagnosis by Microscopy, Rapid Diagnostic Test, and PCR Methods and Evidence of Antimalarial Overprescription in Non-Severe Febrile Patients in Two Tanzanian Hospitals

作者：Nicastri Emanuele; Bevilacqua Nazario^*; Schepisi Monica Sane; Paglia Maria G; Meschi Silvia; Ame Shaali M; Mohamed Jape A; Mangi Sabina; Fumakule Robert; Di Caro Antonino; Capobianchi Maria R; Kitua Andrew; Molteni Fabrizio; Racalbuto Vincenzo; Ippolito Giuseppe

来源：The American Journal of Tropical Medicine and Hygiene, 2009, 80(5): 712-717.

DOI：10.4269/ajtmh.2009.80.712

The study was aimed to evaluate the malaria over/underdiagnosis and over/underprescription of antimalarial drugs. Between February and March 2007 blood samples were collected from 336 non-severe febrile outpatients attended in two peripheral Tanzanian hospitals. Microscopy and a rapid diagnostic test (RDT) were done locally and the accuracy evaluated by qualitative polymerase chain reaction (PCR) for Plasmodium spp. The testing was performed at National Institute for Infectious Diseases Lazzaro Spallanzani (INMI), Rome, Italy. As a result of PCR, we identified 26 malaria cases out of 336 (7.7%) patients. Microscopy and RDT accuracies were 93.5% and 97.6%, respectively. Overprescription and underdiagnosis rates were 29.3% and 30.8%, respectively. On-field training, clinical management of febrile illness, and malaria microscopy in remote settings should be considered.

• 出版日期2009-5
• 单位河北医科大学