Ambulatory arterial stiffness index and nocturnal blood pressure dipping in pregnancies complicated by hypertension

作者：Karkkainen Henna^*; Saarelainen Heli; Laitinen Tomi; Heiskanen Nonna; Valtonen Pirjo; Laitinen Tiina; Vanninen Esko; Heinonen Seppo

来源：Clinical Physiology and Functional Imaging, 2014, 34(1): 39-46.

DOI：10.1111/cpf.12063

• ambulatory arterial stiffness index
• blood pressure
• dipping
• pregnancy

BackgroundThe study sets out to examine differences in arterial stiffness and nocturnal blood pressure dipping as outcomes in women with gestational hypertension compared with healthy pregnant women during pregnancy and 3months after delivery.
Methods and resultsWe prospectively studied a cohort of 60 women during the third trimester of pregnancy; of them, 28 suffered pregnancy-induced hypertension or pre-eclampsia and 32 had uncomplicated singleton pregnancies. Subsequently, 42 of these were re-examined 3months after delivery. In women with a hypertensive disorder, the nocturnal fall in blood pressure (dipping) was significantly smaller than in the normotensive group (systolic, P=0031; diastolic, P<0001), but after pregnancy, this difference disappeared (systolic, P=0941; diastolic, P=0907). Ambulatory arterial stiffness index (AASI) assessed after pregnancy correlated inversely with fasting glucose level during pregnancy (r=-0580, P=0018), both systolic (r=-0651, P=0012) and diastolic (r=-0687, P=0007) nocturnal dipping and total cholesterol concentration after pregnancy (r=-0526, P=0036).
ConclusionsA hypertensive disorder during pregnancy was associated with a flattened circadian blood pressure response, which was restored after delivery. Higher arterial stiffness predicted the signs of postpartum metabolic syndrome and correlated also with non-dipping, especially postpartum.

• 出版日期2014-1