Minireview: The role of the vacuolar ATPase in nematodes

作者：Knight Alison J; Behm Carolyn A^*

来源：Experimental Parasitology, 2012, 132(1): 47-55.

DOI：10.1016/j.exppara.2011.09.004

• Vacuolar ATPase
• Nematode
• Drug target
• Caenorhabditis elegans
• Osmoregulation
• Reproduction

The vacuolar ATPase enzyme complex (V-ATPase) pumps protons across membranes, energised by hydrolysis of ATP. It is involved in many physiological processes and has been implicated in many different diseases. While the broader functions of V-ATPases have been reviewed extensively, the role of this complex in nematodes specifically has not. Here, the essential role of the V-ATPase in nematode nutrition, osmoregulation, synthesis of the cuticle, neurobiology and reproduction is discussed. Based on the requirement of V-ATPase activity, or components of the V-ATPase, for these processes, the potential of the V-ATPase as a drug target for nematode parasites, which cause a significant burden to human health and agriculture, is also discussed. The V-ATPase has all the characteristics of a suitable drug target against nematodes, however the challenge will be to develop a high-throughput assay with which to test potential inhibitors.

• 出版日期2012-9