Super arming of a glycosyl donor using a molecular lever

作者:Olsen Jacob Ingemar; Kowalska Karolina; Pedersen Christian Marcus*; Bols Mikael
来源:Tetrahedron Letters, 2016, 57(1): 35-38.
DOI:10.1016/j.tetlet.2015.11.052

摘要

Novel thiomannosyl donors with a 2,3-(phenyl-1,2-ethylidine) tethering group were designed so that the phenyl group would act as a molecular lever and force the pyranoside into its most reactive conformation. It was demonstrated that this type of molecular leverage could increase the reaction rate at least 200 times.

  • 出版日期2016-1-6