Association of rheumatoid arthritis and the prevalence of metabolic syndrome: an update meta-analysis

作者：Duan, Honghao; Heng, Lisong; Xiao, Lin; Sun, Xiangxiang; Yao, Shuxin; Li, Hui; Zhao, Guanghui; Guo, Hao; Ma, Jianbing^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(9): 17334-17344.

• Rheumatoid arthritis
• metabolic syndrome
• meta-analysis

The aim of the study is to evaluate the association between rheumatoid arthritis (RA) and the risk of metabolic syndrome (MetS). Studies were retrieved in PubMed, Embase and Springer link databases based on predefined searching strategy and inclusion criteria. The Newcastle-Ottawa Scale was utilized to assess the quality of the studies. Odds Ratios (ORs) and 95% confidence intervals (CIs) were utilized to calculate the pooled results. Subgroup analyses were conducted to discuss whether geographic region, study type and sex composition could affect the result. Funnel plot was used to determine the potential publication bias. Seventeen studies containing 3251 RA patients and 5536 healthy controls were identified. As a result, RA patients achieved a higher prevalence of MetS than healthy controls, with the diagnostic criterion of NCEP-ATP III (OR = 1.38, 95% CI: 1.04 to 1.83, P = 0.02), but not with WHO or IDF criterion (P > 0.05). In studies that MetS was diagnosed by NCEP-ATP III criterion, subgroup analysis indicated that there was no significant association between MetS and RA, neither in study type subgroup, nor in region subgroup (P > 0.05). With regard to sex composition, the significant association was detected in male & female group (OR = 1.45, 95% CI: 1.01 to 2.07, P = 0.04), but not female group (P > 0.05). High prevalence of MetS was significantly related to RA, especially when MetS is diagnosed with NCEP-ATP III criterion. However, more prospective studies with larger sample size are required to confirm these results.

• 出版日期2016
• 单位西安交通大学