Amphiphilic graft copolymers with ethyl cellulose backbone: Synthesis, self-assembly and tunable temperature-CO2 response

作者：Yuan, Weizhong^*; Zou, Hui; Shen, Jin

来源：Carbohydrate Polymers, 2016, 136: 216-223.

DOI：10.1016/j.carbpol.2015.09.052

• Graft copolymers
• CO2-responsive
• Temperature responsive
• Self-assembly
• Micelles

Amphiphilic ethyl cellulose-graft-poly(N,N-dimethylaminoethyl methacrylate) (EC-g-PDMAEMA) and ethyl cellulose-graft-poly(2-(2-methoxyethoxy)ethyl methacrylate-co-N,N-dimethylaminoethyl methacrylate) (EC-g-P(MEO2MA-co-DMAEMA)) graft copolymers were easily synthesized by atom transfer radical polymerization (ATRP). The micelles self-assembled from the copolymer presented switchable temperature-CO2 dually responsive properties. The value of lower critical solution temperature (LCST) for the copolymer micelle solutions could be adjusted by CO2/Ar. Moreover, due to the alteration of the ratio of DMAEMA to MEO2MA, the LCST values of the micelle solutions decreased with the increase of MEO(2)MA in copolymer. The temperature-CO2 dually responsive properties of the copolymer were reversible and could be accomplished through altering the temperature and bubbling CO2/Ar. The hydrodynamic radius (R-h) of the copolymer micelles was also influenced by the ratio of DMAEMA to MEO(2)MA and the stimuli of temperature and CO2/Ar. As a drug release system, the copolymer micelles could achieve the control release of doxorubicin (DOX) by changing the temperature and alternatively bubbling CO2/Ar.

• 出版日期2016-1-20
• 单位同济大学