Acute effects of doramectin on gastric acid secretion in anaesthetized rats - a short communication

作者：Erlwanger Kennedy^*; Changara Terence; Sajeni Shepherd; Masara Darlington

来源：Veterinarski Arhiv, 2010, 80(4): 533-537.

• gastric acid
• doramectin
• rats
• gamma amino butyric acid

To investigate the acute effects of doramectin on basal and histamine-stimulated gastric secretion in anaesthetised rats, twenty adult female Sprague-Dawley rats were anaesthetised and their stomachs were cannulated and perfused with saline. Basal gastric acid secretion was collected from all rats. Doramectin (300 mu g.kg(-1), n = 5 and 600 mu g.kg(-1), n = 5) was then administered to ten rats intramuscularly, followed an hour later by histamine (100 mu g.kg(-1)) subcutaneously. In another 10 rats the histamine was administered an hour before the doramectin. There was no significant change in gastric acid secretion compared to when doramectin alone was administered. Histamine, produced a significant increase (P<0.01) in gastric acid secretion. Doramectin neither potentiated nor decreased the effect of histamine on gastric acid secretion.

• 出版日期2010-8