Decreased Time to Treatment Initiation for Multidrug-Resistant Tuberculosis Patients after Use of Xpert MTB/RIF Test, Latvia

作者：Stagg Helen R^*; White Peter J; Riekstina Vija; Cirule Andra; Skenders Girts; Leimane Vaira; Kuksa Liga; Dravniece Gunta; Brown James; Jackson Charlotte

来源：Emerging Infectious Diseases, 2016, 22(3): 482-490.

DOI：10.3201/eid2203.151227

Few studies have examined whether the Xpert MTB/RIF test improves time to treatment initiation for persons with multi drug-resistant tuberculosis (MDR TB). We determined the impact of this test in Latvia, where it was introduced in 2010. After descriptive analyses of pulmonary MDR TB patients in Latvia during 2009-2012, time to treatment initiation was calculated, and univariate and multivariable accelerated failure time models were constructed. Univariate results showed strong evidence of an association between having rifampinresistant TB detected by Xpert MTB/RIF and reduced time to treatment initiation versus the test not being used. A multivariable model stratifying by previous TB showed similar results. Our finding that in Latvia, time to treatment initiation was decreased for MDR TB cases that were rifampin-resistant TB by XpertMTB/RIF has implications for the use of this test in other settings with a high burden of MDR TB in which rifampin resistance is highly predictive of MDR TB.

• 出版日期2016-3