Direct asymmetric aldol reactions in brine using novel sulfonamide catalyst

作者：Miura Tsuyoshi^*; Yasaku Yumi; Koyata Naka; Murakami Yasuoki; Imai Nobuyuki

来源：Tetrahedron Letters, 2009, 50(22): 2632-2635.

DOI：10.1016/j.tetlet.2009.03.053

Direct asymmetric aldol reactions of aldehydes with ketones in the presence of a catalytic amount of sulfonamide 4 and trifluoroacetic acid afforded the corresponding anti-aldol products in moderate to excellent yields with 85-93% ee.

• 出版日期2009-6-3