A new hemodynamic model shows that temporal perturbations of cerebral blood flow and metabolic rate of oxygen cannot be measured individually using functional near-infrared spectroscopy

作者：Fantini Sergio^*

来源：Physiological Measurement, 2014, 35(1): N1-N9.

DOI：10.1088/0967-3334/35/1/N1

• cerebral blood flow
• cerebral blood volume
• cerebral metabolic rate of oxygen
• functional near-infrared spectroscopy
• hemodynamic model

A recent dynamic model relates the functional near-infrared spectroscopy (fNIRS) measurements to hemodynamic and metabolic parameters. This note reports modified expressions of the new model in terms of cerebral blood volume (CBV), blood flow (CBF) and metabolic rate of oxygen (CMRO2). On the basis of these modified expressions, the new model reproduces known steady state relationships between hemoglobin concentration, CBF and CMRO2, and yields time-dependent relationships that describe transient changes. This new model allows for the translation of the fNIRS measurements into dynamic measures of Delta CBV/CBV0 and the difference Delta CBF/CBF0 - Delta CMRO2/CMRO2 vertical bar(0), provided that some baseline physiological parameters and a relationship between overall, arterial and venous blood volume changes are assumed.

• 出版日期2014-1