Diazepam and Fluoxetine Decrease the Stress Response in Zebrafish

作者:de Abreu Murilo Sander; Koakoski Gessi; Ferreira Daiane; Oliveira Thiago Acosta; Santos da Rosa Joao Gabriel; Gusso Darlan; Varrone Giacomini Ana Cristina; Piato Angelo Luis; Gil Barcellos Leonardo Jose
来源:PLos One, 2014, 9(7): e103232.
DOI:10.1371/journal.pone.0103232

摘要

The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Danio rerio. We showed that diazepam and fluoxetine inhibited the stress axis in zebrafish. Intermediate concentrations of diazepam suppressed the stress response as measured by cortisol levels, whereas fluoxetine inhibited cortisol increase at concentrations similar to those found in the environment. These data suggest that the presence of psychoactive drugs in aquatic ecosystems could cause neuroendocrine dysfunction in fish.

  • 出版日期2014-7-23