Acetyl cholinesterase inhibition potential and antioxidant activities of ferulic acid isolated from Impatiens bicolor Linn.

作者：Shahwar Durre^*; Rehman Shafiq Ur; Raza Muhammad Asam

来源：Journal of Medicinal Plants Research, 2010, 4(3): 260-266.

• Acetyl cholinesterase
• FRAP
• ferulic acid
• Impatiens bicolor
• medicinal plant

Ferulic acid was isolated from ethyl acetate extract of Impatiens bicolor Linn. and identified by X-ray analysis. The acetylcholine esterase inhibition, radical scavenging activity (DPPH scavenging assay) and FRAP assay were carried out on the compound. It was found that the effect of ferulic acid was strongly dose dependent i.e., 25 - 175 mu g/ml in DPPH assay, 50 - 150 mu g/ml in FRAP assay and 50 - 200 mu g/ml in acetylcholine esterase inhibition assay. However, ferulic acid did not show significant change in acetylcholine esterase inhibition and antioxidant activity at high concentration.

• 出版日期2010-2-4