Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation

作者：Pocivavsek Ana; Mikhailenko Irina; Strickland Dudley K; Rebeck G William^*

来源：Journal of Neuroimmunology, 2009, 214(1-2): 25-32.

DOI：10.1016/j.jneuroim.2009.06.010

• Apolipoprotein E
• LPS
• Alzheimer's disease
• Signal transduction
• Nitric oxide
• JNK

Apolipoprotein E (apoE)-induced activation of low-density lipoprotein receptor (LDL) family members reduces inflammatory responses by suppressing c-Jun N-terminal kinase (JNK) activation. We aimed to identify which specific receptor family member mediates the effect of apoE on inflammation in primary cultures of microglia. Low-density lipoprotein receptor-related protein 1 (LRP1)-deficient (LRP1-/-) microglia were derived from mice using tissue-specific IoxP/Cre recombination. Using a peptide formed from the receptor-binding region of apoE (EP), we found that LRP1 mediates the effects of apoE on microglial inflammation. Microglial LRP1 was also essential for EP to suppress JNK activation induced by lipopolysaccharide.

• 出版日期2009-9-29