Distinct miRNA profiles are associated with malignant transformation of pancreatic cystic tumors revealing potential biomarkers for clinical use

作者：Frampton Adam E^*; Gall Tamara M H; Giovannetti Elisa; Stebbing Justin; Castellano Leandro; Jiao Long R; Krell Jonathan

来源：Expert Review of Molecular Diagnostics, 2013, 13(4): 325-329.

DOI：10.1586/ERM.13.18

• diagnostic
• intraductal papillary mucinous neoplasm
• IPMN
• miRNA
• pancreatic ductal adenocarcinoma
• PDAC

Pancreatic cysts are now being detected more frequently owing to increased recognition and the liberal use of cross-sectional imaging. There is a spectrum of pancreatic cystic lesions ranging from the completely benign inflammatory to the highly malignant. Pancreatic cystic tumors, especially those with a mucinous epithelial lining such as the intraductal papillary mucinous neoplasms (IPMNs), have the potential to become malignant. The evaluated paper provides further evidence for miRNAs as diagnostic biomarkers for detecting dysplastic and malignant change in IPMNs, which may be useful for future clinical decision making. IPMNs of varying degrees of dysplasia, as well as IPMN with carcinoma, pancreatic ductal adenocarcinoma and normal pancreas samples were examined by microarray. Upregulation of miR-21, miR-155 and miR-708 was found to occur during IPMN malignant transformation. Here, the authors evaluate the published miRNA profiles of premalignant pancreatic lesions in order to consolidate these data.

• 出版日期2013-5