A significant number of women present with palpable breast cancer even with a normal mammogram within 1 year

作者：Haakinson Danielle J; Stucky Chee Chee H; Dueck Amylou C; Gray Richard J; Wasif Nabil; Apsey Heidi A; Pockaj Barbara^*

来源：American Journal of Surgery, 2010, 200(6): 712-717.

DOI：10.1016/j.amjsurg.2010.08.005

• Breast cancer
• Breast cancer screening
• Self breast examination
• Clinical breast examination
• Palpable breast cancer
• Interval breast cancers

BACKGROUND: Although mammography is the gold standard for breast cancer screening, clinical breast examination (CBE) and self breast examination (SBE) are important adjuncts whose utility has been questioned.
METHODS: A retrospective review of invasive breast cancer patients from 2000 to 2008 was performed. We compared 3 groups: breast cancer detected by (1) imaging only (nonpalpable) or palpable mass with a normal mammogram (2) >= 1 year (mammogram >= 1 year) or (3) <1 year (mammogram <1 year).
RESULTS: Of 1,222 women, presentation included 67% nonpalpable, 21% mammogram >= 1 year, and 13% mammogram <1 year. Patients presenting with palpable masses on SBE or CBE even with a normal mammogram within 1 year tended to have more aggressive tumors (larger size, lymph node positive, and triple-negative disease) resulting in more aggressive therapy (a higher mastectomy rate and a greater likelihood of chemotherapy).
CONCLUSION: A significant number of women present with palpable breast cancer within 1 year of a normal mammogram, many with an aggressive cancer. Therefore, we continue to advocate SBE and CBE for breast cancer screening.

• 出版日期2010-12