Microwave assisted synthesis of annelated benzosuberone as new penta-heterocyclic ring systems

作者：Farghaly Thoraya A; Riyadh Sayed M^*

来源：Arkivoc, 2009, 2009(10): 53-64.

DOI：10.3998/ark.5550190.0010.a06

• Penta-heterocyclic ring systems
• hydrazonoyl halides
• microwave irradiation
• benzosuberone

Derivatives of novel penta-heterocyclic ring systems, namely, 5,6,7,11-tetrahydro-15H-benzo[6',7']cyclohepta[1',2':4,5]pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-15-ones (9a-g) and 6,7-dihydrobenzo[6',7']cyclohepta[1',2':4,5]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidin-15(5H)-ones (11a-d) were easily prepared via reactions of 3-thioxo-2,3,4,7,8,9-hexahydro-1H-benzo[6',7']cyclohepta[1',2':4,5]pyrido[2,3-d]pyrimidin-1-one (3) with hydrazonoyl halides and active methylene compounds, respectively. The foregoing reactions were carried out with conventional heating as well as pressurized microwave irradiation and a comparative study was employed.

• 出版日期2009