A Serious Complication of Selected Internal Radiation Therapy: Case Report and Literature Review

作者：Sjoquist Katrin M; Goldstein David^*; Bester Lourens

来源：Oncologist, 2010, 15(8): 830-835.

DOI：10.1634/theoncologist.2010-0074

• Liver neoplasms
• Radiopharmaceuticals
• Peptic ulcer
• Literature review

The use of selective internal radiation therapy (SIRT) with SIR-Spheres (R) (Sirtex, Sydney, Australia) is increasingly recognized as a potential therapeutic modality of primary and secondary malignant liver tumors. A number of treatment-related complications have been described despite technical expertise and detailed pretreatment investigations to assess suitability. We describe a case of gastric ulceration from nontargeted deposition of SIR-spheres (R) in the gastric mucosa with life-threatening consequences. This case highlights the need for careful screening and appropriate patient selection, and the need to recognize ulceration from SIRT as a potential complication of treatment. The characteristic endoscopic, radiologic, and histopathologic findings are illustrated and recommendations are reviewed with regard to the current literature. The Oncologist 2010;15:830-835

• 出版日期2010-8