Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive Patients

作者：d'Ettorre Gabriella; Ceccarelli Giancarlo^*; Andreotti Mauro; Selvaggi Carla; Giustini Noemi; Serafino Sara; Schietroma Ivan; Nunnari Giuseppe; Antonelli Guido; Vullo Vincenzo; Scagnolari Carolina

来源：Mediators of Inflammation, 2015, 2015: 395484.

DOI：10.1155/2015/395484

The complex relationship between both the Th1/Th17 and Tc1/Tc17 axis and innate defences in the intestinal mucosa during HIV-1 infection has not been well characterized. This study examined the frequency, phenotype, and functional status of T cell populations in the gut-associated lymphoid tissue and peripheral blood of virologically suppressed HIV-1-infected patients on therapy, focusing on the Th1, Th17, Tc1, and Tc17 cell subsets. We found a persistent immune cell activation (CD38 and HLADR expression) into the GALT despite the higher levels of Th17 and Tc17 in respect to peripheral blood. An upregulation of type I IFN response in GALT compared to the peripheral blood compartment was also recorded. Furthermore, IFN-alpha/beta levels were negatively related to the frequencies of Th1 naive cells and Tc1 cell subsets (naive, central memory, and effector memory) in the GALT. In contrast, no relationships between type I IFN response and Th1 or Tc1 cell subsets in peripheral blood compartment and between IFN-alpha/beta and Th17/Tc17 in both GALT and peripheral blood district were recorded. These data indicate that prolonged antiretroviral treatment improves GALT immune function despite the persistence of immune activation and type I IFN response in chronic HIV-1 positive patients.

• 出版日期2015