Notch in the niche

作者：Gering Martin; Patient Roger^*

来源：Cell Stem Cell, 2008, 2(4): 293-294.

DOI：10.1016/j.stem.2008.03.016

Notch signaling is essential for hematopoietic stem cell (HSC) formation during embryogenesis, and hitherto it was also thought to be required for HSC maintenance. However, in this issue of Cell Stem Cell, Maillard et al. (2008) demonstrate rather conclusively that inactivation of the Notch pathway in HSCs does not interfere with their self-renewal.

• 出版日期2008-4