Association of metabolic syndrome with atypical features of depression in Japanese people

作者：Takeuchi Takeaki^*; Nakao Mutsuhiro; Kachi Yuko; Yano Eiji

来源：Psychiatry and Clinical Neurosciences, 2013, 67(7): 532-539.

DOI：10.1111/pcn.12104

• atypical depression
• hyperphagia
• Japan
• major depression
• metabolic syndrome

AimIt has been controversial whether metabolic syndrome (MetS) is associated with depression. We aimed to clarify the correlation between MetS and depression, considering atypical features of depression. %26lt;br%26gt;MethodsParticipants were 1011 Japanese men aged 20-59 years. MetS was diagnosed according to criteria set by the International Diabetes Federation. Clinical interviews for major depressive disorder (MDD) employed the DSM-IV; MDD was classified into atypical and non-atypical types. The prevalence of MetS was compared between the groups with no MDD, atypical depression, and non-atypical depression via trend analyses. Multiple logistic regression analyses examined the association of MetS with atypical depression and the features thereof. %26lt;br%26gt;ResultsIn total, 141 (14.0%) participants were diagnosed with MetS and 57 (5.6%) were diagnosed with MDD (14 had atypical and 43 had non-atypicalMDD). The prevalence of MetS was the highest in the group with atypical depression, followed by the non-atypical depression and no MDD groups, respectively, with a marginally significant trend (P=0.07). The adjusted odds ratios of MetS associated with depression were 3.8 (95% confidence interval [CI] 1.1-13.2) for atypical depression and 1.6 (95%CI 0.7-3.6) for non-atypical depression. Among the five features of atypical depression, only hyperphagia was significantly related to MetS (odds ratio 2.7, 95%CI 1.8-4.1). %26lt;br%26gt;ConclusionThere was a positive association between MetS and atypical depression, but not between MetS and non-atypical depression. Specifically, hyperphagia seems to be an important factor affecting the correlation between MetS and atypical depression.

• 出版日期2013-11