AIRWAYS AND CARDIOVASCULAR INHIBITORY EFFECTS OF OLEA EUROPEA AND TERMINALIA BELLERICA AQUEOUS FRACTIONS

作者：Khan Arif Ullah; Gilani Anwarul Hassan^*

来源：Farmacia, 2010, 58(6): 758-763.

• Olea europea
• Terminalia bellerica
• bronchodilator
• vasodilatation
• cardiac inhibitory effect

This study describes the bronchodilatory, vaso-relaxant and cardiac inhibitory effects of aqueous fractions of Olea europea (Oe.Aq) and Terminalia bellerica (Tb.Aq) fruits. In guinea-pig tracheal preparations, Oe.Aq and Tb.Aq caused concentration-dependent (0.03-5 mg/mL) relaxation of carbachol (CCh, 1 mu M) and high potassium (80 mM)-induced contractions. When tested on rabbit aortic rings, against phenylephrine (PE, 1 mu M) and potassium (K+)-induced contractions, Oe.Aq and Tb.Aq caused non-specific inhibition of the induced contractions. In isolated guinea-pig atria, Oe.Aq and Tb.Aq exhibited a suppressive effect on the atrial force and the rate of contractions. These data indicate that Olea europea and Terminalia bellerica aqueous fractions possess airways and cardiovascular inhibitory activities, via calcium antagonism like verapamil.

• 出版日期2010-12