Pioglitazone prevents cavernosal nerve injury after radical prostatectomy

作者：Aliperti Louis A; Hellstrom Wayne J G^*

来源：Medical Hypotheses, 2014, 82(4): 504-504.

DOI：10.1016/j.mehy.2014.01.022

Erectile dysED) is a common consequence of radical prostatectomy (RP) and can affect a man%26apos;s long-term quality of life. Intraoperative manipulation of the neurovascular bundle causes neuropraxia with resultant fibrosis and trabecular smooth-muscle damage. Pioglitazone is an anti-diabetic agent with recognized antifibrotic and vasculoprotective properties, which can protect smooth muscle function. We hypothesize that post-RP pioglitazone therapy can help preserve erectile function.

• 出版日期2014-4