A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers

作者:Han, Jing; Li, Yafeng; Zhan, Lingpeng; Xue, Jinjuan; Sun, Jie; Xiong, Caiqiao*; Nie, Zongxiu*
来源:Chemical communications, 2018, 54(76): 10726-10729.
DOI:10.1039/c8cc06100a

摘要

We report a novel biosensor platform based on competitive non-covalent interaction between ssDNA and a mass tag towards AuNPs, which detects PSA biomarkers sensitively, observed using MALDI MS. A detection limit of 57 pg mL(-1) has been achieved, showing an improvement of two orders of magnitude compared to the traditional spectroscopic method.