An Experimenter's Guide to Glioblastoma Invasion Pathways

作者：de Gooijer Mark C; Navarro Miriam Guillon; Bernards Rene; Wurdinger Thomas; van Tellingent Olaf^*

来源：Trends in Molecular Medicine, 2018, 24(9): 763-780.

DOI：10.1016/j.molmed.2018.07.003

Glioblastoma is a highly aggressive brain tumor that is characterized by its unparalleled invasiveness. Invasive glioblastoma cells not only escape surgery and focal therapies but also are more resistant to current radio-and chemotherapeutic approaches. Thus, any curative therapy for this deadly disease likely should include treatment strategies that interfere with glioblastoma invasiveness. Understanding glioblastoma invasion mechanisms is therefore critical. We discuss the strengths and weaknesses of various glioblastoma invasion models and conclude that robust experimental evidence has been obtained for a pro-invasive role of Ephrin receptors, Rho GTPases, and casein kinase 2 (CK2). Extensive interplay occurs between these proteins, suggesting the existence of a glioblastoma invasion signaling network that comprises several targets for therapy.

• 出版日期2018-9