Nuclear Factor One X Regulates Bobby Sox During Development of the Mouse Forebrain

作者：Dixon Chantelle; Harvey Tracey J; Smith Aaron G; Gronostajski Richard M; Bailey Timothy L; Piper Michael^*

来源：Cellular and Molecular Neurobiology, 2013, 33(7): 867-873.

DOI：10.1007/s10571-013-9961-4

• Bobby sox
• Nuclear factor one X
• Neural progenitor cell
• Transcription factor

The transcription factor nuclear factor one X (NFIX) plays a central role during the development of the neocortex and hippocampus, through the activation of astrocyte-specific gene expression and the repression of progenitor-specific pathways. However, our understanding of transcriptional targets of NFIX during cortical development remains limited. Here, we identify the transcription factor Bobby sox (Bbx) as a target for NFI-mediated transcriptional control. BBX is expressed within ventricular zone progenitor cells within the developing neocortex and hippocampus, and its expression is upregulated in Nfix (-/-) mice. Moreover, we reveal that NFIX can repress Bbx promoter-driven expression. Collectively, these data suggest that Bbx is a downstream target of NFIX during development of the forebrain.

• 出版日期2013-10