Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene with hypertension in Chilean type 2 diabetes patients

作者：Seelenfreund D^*; Lobos S R; Quesada A; Saavedra J M; Wolff C; Lopez Stewart G; Araya A V; Durruty P

来源：Diabetes Research and Clinical Practice, 2012, 96(2): E47-E49.

DOI：10.1016/j.diabres.2012.01.029

• NOS3
• Polymorphism
• Hypertension
• Diabetes mellitus type 2
• Splicing factor SF2/ASF

We investigated two single nucleotide polymorphisms of the NOS3 gene in type 2 diabetic patients (n = 93) and healthy non-diabetic controls (n = 76) and their relationship with smoking habits, body mass index, hypertension and dyslipidemia. Results showed that eNOS polymorphism rs891512 (G24943A) is associated with hypertension in Chilean individuals (p %26lt; 0.05).

• 出版日期2012-5