A new fluorescent material and its application in sulfite and bisulfite bioimaging

作者：Yin, Caixia^*; Li, Xiaoqi; Yue, Yongkang; Chao, Jianbin; Zhang, Yongbin; Huo, Fangjun^*

来源：Sensors and Actuators B: Chemical , 2017, 246: 615-622.

DOI：10.1016/j.snb.2017.02.127

• Sulfite/bisulfite
• Fluorescent
• Detection
• Turn-on
• Bioimaging

In daily life, sulfite and bisulfite have been extensively used as antimicrobial agent and antioxidant for food products, beverages and pharmaceutical products, but, SO32-/HSO3- are fantastically harmful to human health, so it is meaningful to develop an effective probe for these two anions. In this work, a new fluorescent material probe 1 was designed and constructed, which was able to sense sulfite and bisulfite through fluorescence "turn-on" manner. Compared with correlative fourteen other anions used, probe 1 showed great selectivity toward sulfite or bisulfite. Furthermore, the probe can detect SO32-/HSO3- with fast response (within 4min) as well as low detection limit (8.8 nM) compared with the previous work. We characterized the adduct through NMR and X-ray diffraction analysis and further confirmed the detection mechanism of probe 1. Finally, fluorescence imaging of MCF-7 cells indicated that 1 could be used for monitoring SO2 derivatives in living cells with low cytotoxicity.

• 出版日期2017-7
• 单位中国科学院长春应用化学研究所; 山西大学