Atopic dermatitis: phototherapy and systemic therapy

作者:Davis Dawn Marie*; Borok Jenna; Udkoff Jeremy; Lio Peter; Spergel Jonathan
来源:Seminars in Cutaneous Medicine and Surgery, 2017, 36(3): 118-123.
DOI:10.12788/j.sder.2017.027

摘要

The majority of atopic dermatitis (AD) patients respond satisfactorily to gentle bathing, frequent moisturizing, and topical medications. Second-line therapies for AD should be used in recalcitrant cases or in patients with uncontrolled disease despite compliance with first-line measures and avoidance of allergens. Recommended advanced therapies include phototherapy, especially narrowband ultraviolet B, systemic immunosuppressants, and a new biologic agent. Few studies have compared head-to-head efficacy of the different immunosuppressant therapies such as cyclosporine, methotrexate, azathioprine and mycophenolate mofetil.Therefore, the agent used is based on provider and patient preferences and can be decided on a case-by-case basis.