The clinical significance of serum uric acid in patients with Takayasu arteritis

作者：Zhao, Jian-Mei; Li, Xia-Hai; Zhang, Zhao-Xia^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(5): 8276-8281.

• Takayasu arteritis
• serum uric acid
• c-reactive protein

Objective: The study aims to evaluate the association between serum uric acid (UA) and inflammatory markers in patients with Takayasu arteritis (TA), and investigate the change in serum UA concentrations after prednisone therapy in TA patients with active disease. Methods: A total of 117TA patients were divided into active disease groups and inactive disease groups, and forty-eight active patients with TA were followed with standard TA treatment protocol. Results: Serum UA levels in active TA patients were significantly higher than in inactive TA patients (274.9 +/- 77.11 mu mol/L Vs. 238.3 +/- 70.10 mu mol/L, P=0.008). Elevated serum levels of UA showed a positive correlation with C-reactive protein (CRP) in active and inactive TA patients, respectively (r=0.394, P=0.004; r=0.570, P<0.001). In stepwise multiple linear regression analysis, serum UA still remained a positive correlation with CRP in all TA patients after adjustment for multiple confounders (beta=1.445, P<0.001). Serum concentrations of UA were found to be decreased after achieving clinical remission in active patients (274.4 +/- 73.22 mu mol/L vs. 232.1 +/- 45.41 mu mol/L, P=0.001). Conclusions: The present results suggest that serum UA is correlated with CRP in TA patients, and may be a useful tool to assess prednisone treatment effects in active TA patients.

• 出版日期2017
• 单位新疆医科大学