Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum

作者：Gomaa Mohamed N; Soliman Kawther; Ayesh Ahmed; Abd El Wahed Aida; Hamza Zeinab; Mansour Hager M; Khalifa Shaden A M; Mohd Ali Hapipah Bint; El Seedi Hesham R^*

来源：Natural Product Research, 2016, 30(6): 729-734.

DOI：10.1080/14786419.2015.1040991

• soft coral
• Sarcophyton trocheliophorum
• terpenoid
• in vitro
• antimicrobial assays

The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activity towards pathogenic bacterial strains, i.e. Bacillus cereus, Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Bioassay-guided fractionation indicated that the antimicrobial effect was due to the presence of terpenoid bioactive derivatives. Further biological assays of the n-hexane fractions were carried out using turbidity assay, inhibition zone assay and minimum inhibitory concentration for investigating the growth-inhibition effect towards the Gram-positive and Gram-negative bacteria. The fractions were screened and the structure of the isolated compound was justified by interpretation of the spectroscopic data, mainly mass spectrometry (GC-MS). The structure was assigned as (5S)-3-[(3E,5S)-5-hydroxy-3-hepten-6-yn-1-yl]-5-methyl-2(5H)-furanone and was effective at concentrations as low as 0.20mg/mL. The above findings, in the course of our ongoing research on marine products, may implicate that the profound anti-microbial activity of the S. trocheliophorum soft corals, inhabiting the red sea reefs, is attributed to the presence of growth-inhibiting secondary metabolites mainly terpenoids.

• 出版日期2016-3-18