Dioscorin Pre-treatment Protects A549 Human Airway Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Stress

作者：Hsu Jeng Yuan; Chu Jao Jia; Chou Ming Chih^*; Chen Ya Wen

来源：Inflammation, 2013, 36(5): 1013-1019.

DOI：10.1007/s10753-013-9633-z

• adhesion molecules
• A549
• alveolar cells
• dioscorin
• hydrogen peroxide
• NF-kappa B
• IL-8

Hydrogen peroxide (H2O2) is a highly reactive oxygen species involved in lung and bronchial epithelium injury. Increased H2O2 levels have been reported in expired breath condensates of patients with inflammatory airway diseases such as chronic obstructive pulmonary disease. Protecting airway epithelial cells from oxidative stress is an important task in the prevention and management of airway diseases. Previous studies demonstrate that yam (Dioscorea batatas Decne) has antioxidant and anti-trypsin activities. This study evaluated the validity of dioscorin in vitro. The results showed that dioscorin attenuated the alteration of H2O2 on G2/M cell cycle arrest. This might be associated with the activation of I kappa B and subsequent inactivation of NF-kappa B. Furthermore, dioscorin suppressed IL-8 secretion and reduced changes of adhesion molecule expressions in H2O2-injured A549 cells. These results help in understanding the potential of traditional Chinese herbal medicine as treatment for airway inflammatory diseases.

• 出版日期2013-10
• 单位河北医科大学