Molecular characteristics of the MHC-DRA genes from yak (Bos grunniens) and Chinese yakow (Bos grunniens x Bos taurus)

作者：Sun, Y.; Zheng, H.; Xi, D.; Zhang, X.; Du, M.; Pu, L.; Lin, M.; Yang, Y.^*

来源：International Journal of Immunogenetics, 2014, 41(1): 69-73.

DOI：10.1111/iji.12072

• MAJOR HISTOCOMPATIBILITY COMPLEX
• CLASS-II DRA
• COMPARATIVE ORGANIZATION
• EVOLUTION
• POLYMORPHISM
• DIVERSITY
• CATTLE
• LOCUS
• DQA

Two full-length cDNAs (762bp) of the DRA gene from yak and Chinese yakow were isolated and analysed to identify structural and functional variations. The sequences for DRA in yak (Bogr-DRA) and Chinese yakow (BogrxBoLA-DRA) were essentially identical to those for cattle (99%) and buffalo (97%). Except for two substitutions in the amino acids comprising the domain for signal peptide (SP) in yak, the additional residues were highly conserved across the species investigated. Peptide-binding site (PBS) of Bogr-DRA and BogrxBoLA-DRA was highly reserved in the 1 domain among all species investigated. The lack of mutation in Bogr-DRA is consistent with the conception that the gene is highly conserved among all mammalian species. The very high conservation of the DRA gene among ruminants, including yak, may be due to its recent evolutionary detachment.

• 出版日期2014-2
• 单位云南农业大学