科研之友
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摘要
The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson%26apos;s disease within a period of 18 months after implantation. T1-weighted (1.5T) magnetic resonance images were used to determine electrode position in the subthalamic nucleus and the Unified Parkinson%26apos;s disease rating scale (UPDRS-III) was used for motor assessment. The distance of the contacts from the wall of the third ventricle in the mediolateral direction inversely correlated with weight gain (r = -0.55, p%26lt;0.01) and with neurostimulation-related motor condition expressed as the contralateral hemi-body UPDRS-III (r = -0.42, p%26lt;0.01). Patients with at least one contact within 9.3 mm of the wall experienced significantly greater weight gain (9.4+/-(SD) 4.4 kg, N = 11) than those with both contacts located laterally (3.9+/-2.7 kg, N = 9) (p%26lt;0.001). The position of the active contact is critical not only for motor outcome but is also associated with weight gain, suggesting a regional effect of subthalamic stimulation on adjacent structures involved in the central regulation of energy balance, food intake or reward.
- 出版日期2012-5-30
