科研之友
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摘要
A short approach to the tetrahydrofuran fragment of amphidinolides X and Y has been developed through the combination of iterative Sharpless asymmetric epoxidations, Pd-catalyzed regioselective hydrogenolysis of a 4,5-epoxy-2-alkenoate and the disfavored 5-endo-tet ring closure of a beta-hydroxy epoxide promoted by a double bond adjacent to the epoxide function.
- 出版日期2007-4-3
