MTHFR C677T Polymorphism and Colorectal Cancer Risk in Asians, a Meta- analysis of 21 Studies

作者：Yang Zhen^*; Zhang Xie Fu; Liu Hong Xiang; Hao Yong Shun; Zhao Chun Lin

来源：Asian Pacific Journal of Cancer Prevention, 2012, 13(4): 1203-1208.

DOI：10.7314/APJCP.2012.13.4.1203

• MTHFR C677T
• colorectal cancer
• polymorphism
• meta-analysis

Background: Previous studies concerning the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer risk in Asian populations generated conflicting results. A meta-analysis was therefore performed to allow a more reliable estimate of any link. Methods: Relevant studies concerning the association between the MTHFR C677T polymorphism and risk of colorectal cancer were included into this meta-analysis. The quality of the studies was assessed according to a predefined scale. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined for this gene-disease association using fixed or random effect models according to the heterogeneity between included studies. Results: Finally, 21 studies with a total of 6692 cases and 8266 controls were included. Meta-analyses showed that there was an obvious association of the MTHFR 677T allele with decreased risk of colorectal cancer (OR = 0.91, 95% CI = 0.85-0.98, P = 0.011). Subgroup analyses by country further identified this association, with dietary folate as the main source of heterogeneity. Conclusion: The MTHFR 677T allele is associated with a lower risk of colorectal cancer in Asian populations, and there is effect modification by population plasma folate.

• 出版日期2012
• 单位郑州大学