Multimodal voxel-based meta-analysis of structural and functional magnetic resonance imaging studies in those at elevated genetic risk of developing schizophrenia

作者：Cooper Deborah^*; Barker Victoria; Radua Joaquim; Fusar Poli Paolo; Lawrie Stephen M

来源：Psychiatry Research: Neuroimaging , 2014, 221(1): 69-77.

DOI：10.1016/j.pscychresns.2013.07.008

• Functional MRI
• Genetic
• Relatives
• Voxel based morphometry
• Multimodal
• Schizophrenia

Computational brain imaging studies of individuals at familial high risk for psychosis have provided interesting results, but interpreting these findings can be a challenge due to a number of factors. We searched the literature for studies reporting whole brain voxel-based morphometry (VBM) or functional magnetic resonance imaging (tIVIRI) findings in people at familial high risk for schizophrenia compared with a control group. A voxel-wise meta analysis with the effect size version of Signed Differential Mapping (ES-SDM) identified regional abnormalities of functional brain response. Similarly, an ES-SDM meta analysis was conducted on VBM studios. A multi modal imaging meta analysis was used to highlight brain regions with both structural and functional abnormalities. Nineteen studies met the inclusion criteria, in which a total of 815 familial high-risk individuals were compared to 685 controls. Our [NMI results revealed a number of regions of altered activation. VBM findings demonstrated both increases and decreases in grey matter density of relatives in a variety of brain regions. The multimodal analysis revealed relatives had decreased grey matter with hyper activation in the left inferior frontal gyrus/amygdala, and decreased grey matter with hypo activation in the thalamus. We found several regions of altered activation or structure in familial high-risk individuals. Reliable tMRI findings in the right posterior superior temporal gyrus further confirm that alteration in this area is a potential marker of risk.

• 出版日期2014-1-30